Diagnosis and management of common overdose presentations | T&F

Elevated CKMB levels are predictive of mortality following acute paracetamol toxicity.

Ricin is a toxin that is contained in the seeds of the castor oil plant with a structure similar to those listed above. It kills by inhibiting protein synthesis.

Atropine may be used as an antidote to organophosphate poisoning.

Acute methanal poisoning should be treated with ethanol.

Depletion of glutathione stores following acute paracetamol poisoning results in the formation of NABQI.

Cardiac complications of tricyclic toxicity occurs due to agonistic effects on calcium channels.

Suspected paraquat poisoning should be treated immediately with AChE inhibitors  to prevent synaptic degradation of ACh and nicotinic induced overdrive.

Haemodialysis is a recognised treatment modality for arsenic poisoning.

Sodium thiosulphate may be used to treat organophosphate toxicity.

Flumazenil activates the GABA receptor and is used to reverse benzodiazepine